PS268. Relationship between cytokines and dopamine transporter availability in patients with carbon monoxide poisoning

s | 97 Specifically, we examined factors influencing female North Korean refugees’ quality of life. The sample was comprised 172 female North Korean refugees. Participants completed the checklist for Health Condition, the Posttraumatic Stress Disorder Checklist-civilian version (PLC-C; Weathers et al., 1993), the Multidimensional Scale of Perceived Social Support, Zimet et al., 1988), and the Korean version of Short-Form 8-Item Health Survey (SF-8., Han et al., 2004). The Structural Equation Model confirmed the hypothesized mediation model. The measurement model showed a good fit to the data, and all factor loadings were significant (p< .001). The structural model showed a good fit to the data, with the following indices: χ2(38)= 86.184, CFI=.97 NFI=.95, TLI=.96, RMSEA=.08(90% CI: .06, .10). We tested if social support would fully or partially mediate the association between physical and mental health and quality of life, comparing the proposed model with alternative models, confirming the full mediation of the proposed mediation model. “This study was supported by a grant of the Korean Mental Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea(HM15C1054)” PS267 FACTORS THAT EFFECT THE FREQUENCY OF POSTTRAUMATIC STRESS DISORDER (PTSD) IN MILITARY STAFF WHO PARTICIPATES IN MARTIAL OPERATIONS Abdulvahap Gazi Unlu, Cemil Celik, Kamil Nahit Ozmenler Agri Military Hospital, Turkey Abstract Introduction: The aim of this study is to determine the prevalance of PTSD in a special population who participates in martial operations for Turkish Army Forces (TAF) and to detect several factors that play a role in PTSD development. Materials And Methods: The universe of the study is consisted of professional soldiers who participates in martial operations for TAF (n=1150). There are war and/or war-associated traumatic experiences in all individuals of population. 230 volunteers who accept to participate in the study are included to the study by Systematic Sample Selection. Sociodemographic Data Form, Structured Clinical Interview for DSM-IV Axis I Disorders: SCID I) and Clinicial-Administered PTSD Scale: CAPS) are usedIntroduction: The aim of this study is to determine the prevalance of PTSD in a special population who participates in martial operations for Turkish Army Forces (TAF) and to detect several factors that play a role in PTSD development. Materials And Methods: The universe of the study is consisted of professional soldiers who participates in martial operations for TAF (n=1150). There are war and/or war-associated traumatic experiences in all individuals of population. 230 volunteers who accept to participate in the study are included to the study by Systematic Sample Selection. Sociodemographic Data Form, Structured Clinical Interview for DSM-IV Axis I Disorders: SCID I) and Clinicial-Administered PTSD Scale: CAPS) are used for the study. The obtained data was analysed by SPSS package program. Results: No psychiatric diagnosis was detected in 205 (%89,1) of all volunteers. Psychiatric diagnoses have been ranged as the following: 13 (%5,7) PTSD, 2 (%0,9) Major Depressive Disorder, 2 (%0,9) Alcohol Abuse, 1 (%0,4) Panic Disorder, 2 (%0,9) ObsessiveCompulsive Disorder, 1 (%0,4) Generalized Anxiety Disorder and 4 (%1,7) Adjustment Disorder. We found that there was no association between PTSD diagnosis and marital status, educational status, the use of alcohol, psychosocial environmental issues and physical diseases of volunteers and that there was a statistically significant association between PTSD diagnosis and previous psychiatric treatment and tobacco use (P<0,05). Discussion: Because of inability to be follow up of PTSD frequency and inability to be taken into treatment process, we predict that there might be considerably high percentages of chronic PTSD cases in TAF. This may decrease the success rate of ongoing operational tasks and cause an exponential increase of casualties in case of possible battle. We conluded that regular PTSD frequency, follow up and treatment studies in TAF may be important in terms of possible casualties calculations. SUICIDE: PS268 – PS282 PS268 Relationship between cytokines and dopamine transporter availability in patients with carbon monoxide poisoning 1 Wen-Chi Hsieh, 2 Huang Wen-sheng,1 Yuan Hwa Chou 1 Departments of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan 2 Departments of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Abstract Previous studies have demonstrated that dopamine transporter (DAT) decreased in patients with carbon monoxide poisoning (COP). However, the underlying mechanism is unclear. COP may cause neuropsychiatric symptoms, which result from a demyelinating leukoencephalopathy caused by the injury or destruction of myelin and/or oligodendroglia in the cerebral white matter. The aim of this study was to examine the relationship between DAT and cytokines in patient with COP. Thirty-three patients with COP and 33 agesex-matched healthy controls (HCs) were recruited. Each subject underwent single photon emission computed tomography with [99mTc] TRODAT-1 to measure DAT availability. Cytokines included the pro-inflammatory cytokine tumor necrosis factor-α(TNF-α) and the anti-inflammatory cytokine interleukin-10 (IL-10), which was measured using an enzyme-linked immunosorbent assay. The total striatal DAT was significantly lower in COP than HCs (3.01 ± 0.73 vs. 2.41 ± 0.62, t=3.587, p=0.001). In a sub-analysis showed that both sides of DAT were decreased. TNF-α was significantly lower in COP than HCs (4.63 ± 6.79 vs. 1.08 ± 0.36, t=2.714, p=0.012), whereas IL-10 was not different in both groups (4.31 ± 3.31 vs. 4.93 ± 1.10, t=-1.000, p=0.321). Linear regression analysis showed that IL-10 was well correlated with the decreased DAT in HCs but not in COP (HCs: β=0.72, p=0.000; COP: β=0.22, p=0.247). Our results implicate that the disruption of association of DAT and IL-10, which was found in HCs, might be an important factor underpinning the decreased DAT.Previous studies have demonstrated that dopamine transporter (DAT) decreased in patients with carbon monoxide poisoning (COP). However, the underlying mechanism is unclear. COP may cause neuropsychiatric symptoms, which result from a demyelinating leukoencephalopathy caused by the injury or destruction of myelin and/or oligodendroglia in the cerebral white matter. The aim of this study was to examine the relationship between DAT and cytokines in patient with COP. Thirty-three patients with COP and 33 agesex-matched healthy controls (HCs) were recruited. Each subject underwent single photon emission computed tomography with [99mTc] TRODAT-1 to measure DAT availability. Cytokines included the pro-inflammatory cytokine tumor necrosis factor-α(TNF-α) and the anti-inflammatory cytokine interleukin-10 (IL-10), which was measured using an enzyme-linked immunosorbent assay. The total striatal DAT was significantly lower in COP than HCs (3.01 ± 0.73 vs. 2.41 ± 0.62, t=3.587, p=0.001). In a sub-analysis showed that both sides of DAT were decreased. TNF-α was significantly lower in COP than HCs (4.63 ± 6.79 vs. 1.08 ± 0.36, t=2.714, p=0.012), whereas IL-10 was not different in both groups (4.31 ± 3.31 vs. 4.93 ± 1.10, t=-1.000, p=0.321). Linear regression analysis showed that IL-10 was well correlated with the decreased DAT in HCs but not in COP (HCs: β=0.72, p=0.000; COP: β=0.22, p=0.247). Our results implicate that the disruption of association of DAT and IL-10, which was found in HCs, might be an important factor underpinning the decreased DAT. PS269 Epidemiology of Completed Suicide in Different Blood Alcohol Concentration: a Nationwide Autopsy-based Study Jae Won Lee, Yong Min Ahn, Sung Joon Cho, C. Hyung Keun Park,